Child of Five Years with Gall Stones: Removal of Spleen and Gall Bladder

The development of symptomless cyanosis followed the administration of drugs of the sulphonamide groups. The simultaneous administration of magnesium sulphate is to be noted as a probable etiological factor. Colebrook', in his first series of forty cases, all of whlIoim were taking magnesium sulphate, had three cases of sulph<moglobinaemia. In his second series2 of twxenty-six cases similarly treated with Prontosil, but excluding miagnesium sulphate, no case of cyanosis was observed. The possible association of magnesium sulphate with an azo dye in producing sulphc-emoglobinxiimia was mentioned bv Van den Bergh and Revers.3 Recovery from the condition was spontaneous, and apparently no ill-effects result. I am indebted to Professor \V. XI. D. Thomson for advice and assistance, Professor D. C. Harrison for the spectroscopic examinations, and Dr. A. Gardner Robb for permission to record the case.